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Rare but Serious Complications Even though rare, serious problems can happen with Vitamin B12 shots
J Clin Med
Some patients have also experienced a hypersensitivity reaction following intramuscular injection that has resulted in anaphylactic shock and death
If irritation continues to occur, apply an over-the-counter itch cream, preferably with hydrocortisone, or discontinue use entirely
A 50mg vial is often a practical starting point for smaller pilot studies, initial dose-response testing, or first-time researchers who want to confirm handling and reconstitution before scaling up
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