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Tirzepatide, a dual glucagon-like peptide-1 (GIP) and GLP-1RAs, administered once weekly at a 15 mg dose, resulted in an average weight loss of 20.9% over 72 weeks (Jastreboff et al., 2022), driven by its synergistic effects on appetite regulation, energy intake reduction, and fat mass decrease (Heise et al., 2023)

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Eligible patients were randomized in a 1:1:1:2 ratio into one of four treatment groups: GIC-1001 at doses of 250 mg, 375 mg, or 500 mg, and a matching placebo group

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