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Ferroptosis directly affects adipose tissue and indirectly promotes the development of obesity through inflammation and insulin resistance caused by regulatory disorders in the liver and immune system
196 When the Wnt/-catenin pathway is activated, it can reduce lipid ROS production in gastric cancer cells, and the -catenin/TCF4 transcription complex can directly bind to the GPX4 promoter region, enhancing its expression and thereby inhibiting cell ferroptosis
Liu Y, Moural T, Koirala B K S, Hernandez J, Shen Z, Alyokhin A
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