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Thornburgh, S., & Gaskins, A
Table of Contents: What is Semaglutide GLP-1, and how does it aid in weight loss
Phase 2 trial data (published in New England Journal of Medicine, 2023 ): 24.2% average weight loss at 48 weeks with 12 mg dose 22.8% with 8 mg dose Placebo group lost 2.1% Most recent Phase 3 trial data (TRIUMPH-4, December 2025): 28.7% average weight loss at 68 weeks with 12 mg dose 26.4% with 9 mg dose 58.6% of participants on 12 mg achieved at least 25% weight loss 39.4% achieved at least 30% weight loss For context: These are the highest weight loss numbers reported in any clinical trial for a pharmacological obesity treatment
Exercise, vegetarianism, even SlimFast
The correlation analysis was performed defining the AUC of either early-phase breath hydrogen (60180 min after the start of the test) or second-meal breath hydrogen (210300 min after the start of the test) as the independent variable and the AUC of second-meal desire-to-eat ratings (210300 min after the start of the test) as the dependent variable
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