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Diagn Res

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(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)

Additionally, consuming foods high in vitamin C, such as citrus fruits and strawberries, can help support glutathione production

TRPM8 mechanism of cold allodynia after chronic nerve injury