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These hallmarks encompass genomic instability, the shortening of telomeres, deregulated nutrient sensing, mitochondrial dysfunction, changes in epigenetic regulation, loss of proteostasis, cellular senescence, stem cell exhaustion, and altered intercellular communication (Campisi et al., 2019)

Based on clinical trial data, retatrutide produces greater average weight loss (28.7% at 68 weeks with 12mg) compared to tirzepatide (22.5% at 72 weeks with 15mg)

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Pharmacology research & perspectives

What downstream signalling cascade does LHCGR activation initiate