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According to a large, randomized controlled study, at the maximum dose of Ozempic for weight loss, obese patients lost an average of 6% of their body weight at week 12, 12% at week 28, and 15% at week 68
While it has been always believed that this increase was due to an adaptive response of -cells aimed at compensating for altered insulin sensitivity, there is much evidence to support the hypothesis that -cell hyperactivity, which can eventually lead to their failure, precedes the onset of insulin resistance
Common side effects with daily oral dosing Nausea is the most reported side effect
So what's the take-home message
Diabetologia 66(6):10161023
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