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It's important to note that as you lose weight, your calorie needs will decrease, and your target may need periodic adjustment

Aringer et al

Another SURMOUNT-3 analysis 208 demonstrated that tirzepatide improved health-related quality of life scores in obese/overweight adults, with greater benefits observed in those achieving higher weight loss thresholds and in those without baseline functional limitations

Neither peptide is FDA-approved for anything

Both medications can lead to weight lossOzempic through its effects on satiety and gastric emptying, and Topamax through appetite suppression and altered taste sensation