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The selectivity of FOXO4-DRI appears to be a major advantage: FOXO4-DRI peptide is particularly compelling due to its ability to disrupt the FOXO4-p53 interaction , a critical regulator of cellular senescence

, of Sweden

Klotz P et al

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As adrenal cortex hormone depletion progresses (Phase A pathology), overall adrenal function is compromised as the cortisol, estrogen, and thyroid functions have become dysregulated, leading to OAT axis imbalance (Phase B pathology)