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Currently, these methods rely on detecting any one of the elements present in the presynaptic or the postsynaptic neuron, be it a morphological feature such as a change in dendritic spines (small dynamic protrusions located along the dendrites), or variations in the expression of a specific protein from the synaptic vesicle cycle or the postsynaptic density (PSD, an electron-dense structure located beneath the postsynaptic neurons membrane, usually at the tip of the dendritic spine) (see Figure 1)