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PMID 18272931.

Hayes JD, Flanagan JU, Jowsey IR

However, this distinction is not always achievable in practice

Dedicated long-term trials investigating the benefits of such therapies on hospitalisation, major cardiovascular adverse events and all-cause mortality are required

According to FDA guidance, GLP-1 medications are not recommended for people who have: Pregnancy, because safety data are limited and pregnancy requires appropriate weight gain and nutrient storage A prior history of pancreatitis, due to a risk of triggering inflammation of the pancreas A history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2), a rare genetic condition linked to thyroid cancer in animal studies A clinician will review your medical history carefully to determine whether these medications are appropriate for you