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In terms of mucosal infection susceptibility, the Dectin-1 Y238X heterozygote significantly increases the risk of RVVC, and is associated with a higher Candida colonization rate in patients with hematological malignancies, requiring more frequent prophylactic antifungal treatment (Rosentul et al., 2011)
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It is important to note that, although there is some evidence of immunological biomarker disturbances at lowmoderate altitudes in elite athletes [91, 92] and anecdotally there is an assumption of increased rate of illness at altitude, there is actually limited evidence of an increased rate of illness at lowmoderate altitudes
