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Clinical trial data using body-composition analysis show that fat mass accounts for the majority of weight loss, while lean-mass changes reflect normal physiologic adaptation to reduced body weight and energy intake. Understanding this distinction is criticalbecause muscle wasting and expected lean-mass adaptation are not the same thing

Appetite and weight changes are among the most noticeable effects after stopping GLP-1 therapy

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Sleep-maintenance insomnia: you fall asleep, then wake up and cant get back down