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Mounjaro vs Retatrutide: Combining the Two (Rationale + Risk) At a glance Mounjaro mechanism / dual agonist: GIP + GLP-1 receptors Retatrutide mechanism / triple agonist: GIP + GLP-1 + glucagon receptors Mounjaro approval status / FDA-approved since May 2022 for type 2 diabetes Retatrutide approval status / investigational