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Glickman says: Side effects such as nausea may impact adherence for some patients, but these are generally manageable with both medications. And while Ozempic probably works a little bit better at lowering blood sugar and promoting more weight loss, Trulicity tends to have fewer side effects, adds Brynna Connor, MD, Healthcare Ambassador at NorthWestPharmacy.com Should you consider compounded meds

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If weight loss occurs, it usually begins within the first few weeks of starting the medication