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Wallis C, Holcombe LJ

(18) People who have chronic fatigue syndrome have lower levels of glutathione and do not efficiently produce more within the body

The oxidative stress is the result of the imbalance of the antioxidant system in favor of prooxidants, which interferes with the GSH/GSSG system in the antioxidant defense and the regulation of gene expression, the synthesis of DNA and proteins, cell proliferation and apoptosis, and cytokine production and protein glutathionylation, due to alteration of certain cellular functions