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Regulatory and compounding status All four compounds share a broadly similar regulatory landscape in the United States as of 2026: None are FDA-approved as finished drug products for therapeutic use All are classified as WADA S2 prohibited substances year-round All four have 503A compounding status of Under Review, meaning the FDA Pharmacy Compounding Advisory Committee (PCAC) has nominated them for evaluation but final category assignments (Category 1 permitted for compounding

NAD+ is a coenzyme your cells need to produce energy

While they share a common purpose stimulating the bodys own growth hormone production they differ meaningfully in structure, duration of action, dosing protocols, and clinical applications

WADA has determined that these routes of administration result in a significant level of glucocorticoids circulating in the blood, which has the potential to result in performance enhancement or cause harm to health

Preclinical studies showed lipolytic and anti-lipogenic effects, but human trials failed to demonstrate significant weight-loss outcomes