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3,4 Choline TMA-lyase (CutC) catalyzes the production of TMA from choline

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demonstrated for the first time that TMAO can bind and activate PERK to cause atherosclerosis, which provides a new mechanism of action of TMAO-induced atherosclerosis, which will be described in detail below (10)

In a separate study, phenobarbital induced NADPHcytochrome c reductase, glutathione reductase, cytochrome P450, and UDP-glucuronosyltransferase equally in the centrilobular and periportal hepatocytes

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