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Elucidating the efficacy of antihypertension interventions will likely require long-term follow-up of participants beginning in midlife and employing cognition as a primary rather than secondary outcome measure (Cunningham et al., 2021)

GLP-1 receptor agonists (semaglutide, liraglutide, tirzepatide) act on the brain as well as the gut, and a 2026 real-world cohort study from Kamel-Abusalha et al

These metabolic changes are happening before the visible transformation begins

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Dietary considerations may also prove beneficial