Cellular stress, excessive apoptosis, and the effect of metformin in a mouse model of type 2 diabetic embryopathy
For example, in the fruit fly Drosophila melanogaster model, an incompatibility in the interaction between the mt-tRNA Tyr and mt-tyrosyl-tRNA synthetase variants encoded by the mitochondrial and the nuclear genomes, respectively, resulted in compromised OXPHOS, and weakened the innate immune response against a bacterial pathogen [15]
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