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NICEs guideline covers recognising and managing B12 deficiency in adults, including deficiency linked to autoimmune gastritis

Study Approval All animal experiments were approved by the Animal Research Committee, Graduate School of Medicine, Kyoto University (MedKyoto20187), and were conducted in accordance with the Guide for the Care and Use of Laboratory Animals (National Institutes of Health, Bethesda, MD)

Int J Rheum Dis 2011

Frequency: one subcutaneous injection each day for 812 weeks (optionally extended to 16)

The surface modification of blood exosomes with transferrin-conjugated superparamagnetic nanoparticles via interaction with the transferrin receptor, with L17E endosomolytic peptides (IWLTALKFLGKHAAKHEAKQQLSKL) via electrostatic interactions, and with cholesterol-conjugated miR-21 inhibitor by anchoring to the lipid membrane increased tumor accumulation and drug delivery and enabled efficient endosomal escape 40