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To check whether these SNPs are associated with CVD or its risk factors via other phenotypes rather than via l-carnitine, we also assessed the association of these selected SNPs with potential causal factors for CVD, including Townsend index, education, smoking, and alcohol drinking in the UK Biobank, which are well-known factors affecting CVD and possibly l-carnitine

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The specific mechanism of oxidative stress has been reported as follows: nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) on the cell membrane, activated by upstream stimuli, provides electrons to oxygen and form superoxide (O 2 )