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Although IL-17A-targeted biologics demonstrate efficacy in diseases like psoriasis, their early clinical trials in COPD including the CNTO6785 study encountered translational bottlenecks (44)
Because they are easy to use and do not require injections, nasal sprays have become a more widely discussed option
these cytokines are produced primarily by adipocytes, tissue-resident macrophages, and infiltrating immune cells (e.g., Th17 cells and other T lymphocytes) within the adipose tissue, which can exacerbate keratinocyte activation and immune dysregulation in psoriatic skin (48)
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As such, the efficacy results presented here, although promising, are still preliminary and subject to further validation
