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Persistent vomiting or diarrhoea can lead to dehydration, which in turn may increase the risk of acute kidney injury a class-relevant concern also noted in the Summary of Product Characteristics (SmPC) for approved GLP-1 receptor agonists such as semaglutide

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By interacting with GLP-1 receptor signaling pathways, Semaglutide has been explored in research involving: Glucose-regulation mechanisms Insulin-signaling pathways Appetite and satiety-related research Gastric-emptying investigations Adipose and body-composition models Metabolic and cardiometabolic-related pathways Experimental research has also investigated Semaglutide in models related to: Energy-balance regulation Food-intake and satiety-related pathways Metabolic-efficiency investigations Glucose-homeostasis research Body-composition and adipose-related research models These pathways have contributed to growing scientific interest in Semaglutide within metabolic and obesity-related research models