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GLP-1 Rs are abundantly expressed on stomach-innervating vagal afferent neurons which are critical for detecting gastrointestinal stretch and transmitting this information to the nucleus tractus solitarius (NTS
In our short-term study, small reductions after survodutide treatment were observed in NASH-related scores (Fib-4 score, APRI, NAFLD fibrosis score) and in the ELF score, and potentially clinically relevant reductions were observed in the fibrogenic biomarker Pro-C3
By the late 1990s, the pieces were in place: GLP-1 was a validated target , and prototype therapeutic agents (exendin-4 and a few modified human GLP-1 analogs) were entering clinical testing
For a deeper dive into these differences, see our tirzepatide vs retatrutide comparison
GIPs effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(330)NH2
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