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And it's a history with its share of ignominy: In the mid-1990s, a drug that combined fenfluramine and phentermine, known as fen-phen, exploded in popularity after a single, 121-patient study showed it was effective for weight loss
Ambiguous and, according to the authors of the analysis, inconclusive effects of GLP-1RAs on psychiatric symptoms were revealed
Additionally, weight loss and dietary changes (vitamin K intake) can alter warfarin dose requirements
Sano R, Shinozaki Y, Ohta T
The reason matters because it determines whether switching medications will actually help, or whether the real fix lies somewhere else entirely
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