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doi: 10.1210/jc.2012-3855 205 KimMPlattMJShibasakiTQuagginSEBackxPHSeinoSet al

In the action in diabetes and vascular disease (ADVANCE) trial, a study involving 11,140 subjects with T2DM who were followed for a median duration of 4.4 years, a higher HR was associated with a significantly increased risk of all-cause mortality, cardiovascular death, and major cardiovascular events (death, nonfatal acute myocardial infarction [AMI] or nonfatal stroke) [39]

Injection site reactions occur in 14% of users, typically presenting as mild redness, itching, or temporary discomfort at the injection location