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Table of Contents How Retatrutide Works in the Body Retatrutide is a triple receptor agonist that activates GLP-1, GIP, and glucagon receptors simultaneously, reducing appetite, improving insulin secretion, and potentially increasing energy expenditure and fat breakdown

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Cardiovascular Safety The SELECT trial evaluating cardiovascular outcomes in patients with obesity and established cardiovascular disease demonstrated that serious adverse events were actually lower with semaglutide versus placebo (33.4% vs 36.4%), primarily driven by fewer cardiac disorders (11.5% vs 13.5%)

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How do different GLP-1 medications compare in terms of gastroparesis risk