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However, in specifically designed placebo-controlled studies of GLP-1 RAs among patients with HFrEF, there were no improvements in HRQoL

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The LEADER trial with liraglutide and the REWIND trial with dulaglutide did not show significant increases in retinopathy complications, though differences in trial design, patient populations, baseline retinopathy prevalence, and rates of glycemic improvement may explain these discrepant findings

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Outsourcing facilities operate under section 503B of the Federal Food, Drug, and Cosmetic Act and are the source for much of the compounded GLP-1 supply that has reached patients through telehealth platforms