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Darkening of existing moles and freckles (melanocytes in moles respond to melanocortin activation monitor any moles for asymmetric or irregular changes)

DNA Repair 71 , 177182 (2018)

GLS1 levels reportedly increase following mTOR inhibition 57,58 , and we have previously proposed the combination of a GLS inhibitor and aspirin, an mTOR inhibitor, for the treatment of PIK3CA -MT colorectal cancer