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Uptake of reduced iron is mediated by Leishmania iron transporter 1 (LIT1), an iron-responsive transporter essential for parasite replication and virulence (68, 69) Similarly, Leishmania heme response 1 (LHR1), present in the plasma membrane and endocytic compartment, promotes heme transport to the cytosol and its absence attenuates parasite virulence (73, 74)