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How much to increase by Standard increases follow the dose doubling pattern used in clinical trials

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Patients should never attempt to self-prescribe or self-escalate doses based on published trial data

122 showed the difference between the pharmacokinetic profile in preterm babies and adults caused by immature liver and poor renal excretion and concluded that a 2-h infusion of 0.1 g/kg/h increased plasma melatonin from undetectable to approximately peak adult concentration

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