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Based on the mechanism of skin irritation, we examined and proposed an approach to assess the skin irritation potential of copper compounds using cytotoxicity assay, gene and protein expression levels of cytokines

In vitro studies are powerful for mechanistic precision, but they are simplified systems

doi:10.1007/s00125-004-1342-6 Grant SF, Thorleifsson G, Reynisdottir I, et al

Curcumin enhances neurogenesis and cognition in aged rats: implications for transcriptional interactions related to growth and synaptic plasticity

If none of those apply and you eat a varied diet that includes animal products, your B12 status is less likely to be a concern during treatment