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These medications can be highly effective for weight loss and metabolic health, but they also come with side effects, high costs, and the need for lifestyle changes to maintain results

In the U.S., they are not FDA-approved for human use but are available for research purposes

What dose

Behavioral intervention consisted of counseling by a dietitian or similarly qualified healthcare professional every 4 weeks via in-person visits or telephone on adherence to a reduced-calorie diet (500 kcal deficit a day relative to the energy expenditure estimated at randomization) and increased physical activity (150 minutes a week encouraged, for example, walking), both recorded daily (via a diary, app or other tools, which were reviewed during counseling sessions)