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these include: Underlying bacterial infection or toxin-related rash (eg, staphylococcal scalded skin syndrome and toxic shock syndrome) Viral exanthems, including measles, rubella, human immunodeficiency virus (HIV), roseola due to human herpes-virus 6, Epstein-Barr virus and many others Irritant contact dermatitis Folliculitis Sweat-induced miliaria or transient acantholytic dermatosis (Grover disease) Erythema multiforme due to non-drug causes Idiopathic generalised pustular psoriasis (AGEP may mimic this) Non-drug-induced cutaneous lupus erythematosus Autoimmune blistering diseases Other causes of erythroderma (eg, eczema, psoriasis, and lymphoma)

These symptoms are most noticeable during the first 12 weeks of treatment, often referred to as the dose-escalation phase

10.1016/s0928-4257(97)89480-6 102 SelyeH.SzaboS

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Sano S, Yokoyama K, Fukushima M, Yagi T, Nagao Y