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In a 48-week phase 2 trial published in The New England Journal of Medicine , adults with obesity (without type 2 diabetes) receiving once-weekly subcutaneous retatrutide at the 12 mg amount achieved a least-squares mean body weight reduction of 24.2%, compared with 2.1% in the placebo group [1]

The protective effects of rapamycin on cell autophagy in the renal tissues of rats with diabetic nephropathy via mtor-S6k1-lc3ii signaling pathway