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Lillys pursuit of small-molecule GLP-1s like orforglipron indicates a strategic move to fully chemical manufacturing, which if successful could shift manufacturing out of peptide processes entirely

The 12mg dose group in the Phase 2 trial had substantially more GI side effects than the 4mg group

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Through high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based molecular weight identification, standard molecular weight comparison, and characteristic HPLC profiles of the [ 3 H]proline and [ 3 H]BPC157 standards (Supplementary Figure S2), we speculated the structures of these six components and designated them as M1M6 (Table 10)