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Both physiological and pathological stimulations were performed
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The chronic inflammatory environment degrades existing collagen faster than the body can replace it, and the disorganized keratinocyte proliferation further disrupts normal tissue structure
For example, excessive alcohol consumption promotes the translocation of intestinal -glucan to the liver, where it binds to Dectin-1 on liver macrophages, activating the NLRP3 inflammasome and contributing to the development of alcoholic hepatitis (Wu et al., 2020b)
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