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While beneficial effects are observed when compounds trigger bias at the GLP-1R towards G protein signalling ( Genetic variation at the incretin receptors The most direct answer to why people fail to respond to incretin therapies is that they might express non-functional incretin receptors

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If you have too much of that intervention, like the full dose of the drugs, you're probably thinking okay, I'm going to become dependent and I'm not really going to learn the thing because I'm getting miswired signals to my brain, right, just by virtue, by definition of how it works

Because food intake drops so significantly, theres a real risk of developing vitamin or nutrient deficiencies while on these medications