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Research suggests that NNMT inhibition may influence metabolic pathways related to energy expenditure, fat metabolism, and cellular vitality

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To have a side effect to that is contradictory to how your biochemistry naturally works

In adipose tissue, elevated NNMT activity is strongly correlated with obesity, insulin resistance, and cellular aging

Groups vulnerable to these deficiencies include individuals dealing with obesity, impaired nutrient absorption, renal issues, proton pump inhibitor (PPI) users, elderly individuals with elevated Clinical Frailty Scores, women, taller individuals, and post-bariatric surgery patients, especially those lacking postoperative care [3, 43,44,45]