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PERK regulates Nrf2/ARE antioxidant pathway against dibutyl phthalate-induced mitochondrial damage and apoptosis dependent of reactive oxygen species in mouse spermatocyte-derived cells

It has been proposed that the severity of peripheral neuropathy is inversely proportional to the level of vitamin E, while chemotherapy-induced vitamin E deficiency makes the nervous system more vulnerable

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Evidence for this action has been demonstrated in mice (Fridolf et al., 1991), rats (de Heer et al., 2008), dogs (Freyse et al., 1997), and humans in vivo (Hare et al., 2009), as well as in intact isolated mouse islets (De Marinis et al., 2010)