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BCKAs can be irreversibly oxidized by branched-chain ketoacid dehydrogenase (BCKDH) to form branched-chain acyl-CoA (BC Acyl-CoA) thioesters isovaleryl-CoA (IV-CoA), methylbutyryl-CoA (MB-CoA), and isobutyryl-CoA (IB-CoA), which are retained in the mitochondria for further oxidation to enter the tricarboxylic acid (TCA) cycle as either acetyl-CoA or succinyl-CoA
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10.1016/j.neurobiolaging.2021.07.014 138 IshiguroH.KodamaS.HorikawaC.FujiharaK.HiroseA
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