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In the primary endpoint of mean percent change in body weight from an average baseline of 223.5 lb., orforglipron 36 mg, taken once daily without food and water restrictions, lowered weight by an average of 10.5% (22.9 lbs) vs
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For standard-release tablets, the usual maintenance dose is 1,000 mg twice daily, with a maximum of 3,000 mg daily in divided doses (though many patients are maintained on 2,000 mg daily)