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Another study showed that in JHU-083-treated cancer cell allograft models, an increase in nutrient levels and oxygen and a decrease in the acidity of the TME resulted in T-cell-mediated tumor suppression 145 , whereas another study demonstrated the effects of JHU-083 on myeloid-derived suppressor cells (MDSCs) and TAMs 150

Caution is advised in patients with a history of pancreatitis or severe renal impairment

Its really, I think, a very bright future for this area of medicine, Drucker says.