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[234] [200] In addition to presynaptic actions that regulate DAT, TAAR1 activation exerts a somatodendritic inhibitory influence on midbrain dopamine neurons by reducing their firing rate via G protein-coupled inwardly-rectifying potassium channels, an effect that is expected to reduce action potential-dependent (vesicular) dopamine release into the synaptic cleft
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Int Immunopharmacol 8(7):967973
A target of 0.1 g/dl was utilized to allow for a 20% variance between blood alcohol content (BAC) and BrAC 51,52
Common side effects of GLP-1RAs include gastrointestinal reactions such as nausea, vomiting and diarrhea (Wolffenbuttel et al., 2023)
