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Its essential for converting food into energy (ATP), repairing damaged DNA, and regulating key cellular processes

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Moreover, pathways mediating ferroptosis in breast cancer include T-cell inhibition via GCH1-BH4 [74] and ferroptosis triggered by DHODH-CoQH2 following GPX4 inactivation [75]

revealed that under chemotherapy-induced stress, lactate increasingly enters the TCA cycle of TNBC cells, accompanied by enhanced mitochondrial OXPHOS 47