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Forty-two four-week-old male Sprague-Dawley (SD) rats were divided into seven groups: anti-LOX, control, VED, HCG, anti-LOX and VED, VED and HCG, and VED+HCG+anti-LOX

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As a more severe procedure, chronic unpredictable stress (after 5 d of unpredictable stress protocol, once daily drug application during stress procedure, open field-immobility test assessment at fourth or sixth day of medication) was used

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