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doi: 10.1056/NEJMoa1603827 13 MarsoSPBainSCConsoliAEliaschewitzFGJodarELeiterLAet al

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CJC-1295 Without DAC (Mod-GRF 1-29) pharmacological characterisation: Studies characterising the tetrasubstituted Mod-GRF 1-29 sequence established that the four amino acid substitutions produce a DPP-IV-resistant, endopeptidase-stable GHRH analogue with approximately 30-minute plasma half-life substantially extended versus native GHRH(1-29) without the albumin-binding continuous release profile of the DAC variant

S5A), suggesting that the deletion of Gclc was localized to the liver