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Because it competes at the nicotinamide substrate site rather than the SAM cofactor site, it is also used as the substrate-competitive reference compound against which bisubstrate and covalent NNMT inhibitors are benchmarked

Comparison with Related Therapies Growth Factors and Regenerative Medicine Approaches BPC-157 and TB-500 can be compared to other growth factors and regenerative medicine approaches used in clinical practice

Most critically, patients with active malignancies or significant cancer risk factors may not be appropriate candidates due to the potential for promoting tumor growth and metastasis through angiogenesis stimulation