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In humans, creatine synthesis has been reported to account for 70 % of Hcy formation ( Reference Mudd and Poole 18 , Reference Mudd, Ebert and Scriver 19 )

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According to another analysis [34], the published results, as a rule, show an improvement in some brain parameters (for example, hippocampal connectivity, glucose metabolism in the brain, hippocampal activation according to functional magnetic resonance imaging), but could not demonstrate a strong correlation with cognitive indicators